Director, Medicinal Chemistry [China]


 

职位描述:

As a medicinal chemistry leader, drive and direct medicinal chemistry functions for one or more drug discovery projects. The main job functions include:
  • Working in concert with partners in molecular and cellular biology, pharmacology, molecular informatics, ADME, structural biology, chemical development, and other key functions;
  • Analyze screening data, perform literature reviews, design, propose, and execute medicinal chemistry plans, coordinate chemistry and biology data to support compound progression and patent strategies;
  • Involved in supervising and/or directing synthetic chemistry activities internally;
  • Participate in shaping and implementing strategies that support Medicinal Chemistry growth objectives;
  • Serve as a scientific expert in medicinal chemistry and provide recommendations regarding new targets and emerging external opportunities;
  • Ensure optimal interaction/communication and provide updates on project status to the client.

任职资格:

  • PhD in synthetic or medicinal chemistry is required, preferably with postdoctoral experience
  • At least 5+ years of experience in the biotechnology or pharmaceutical industry with a proven track record of innovative projects and key contributions to clinical candidate selection.
  • Prior project leadership is required
  • Broad experience and proven accomplishments in a field of Medicinal Chemistry, preferably in one or more fields of oncology, immunology and virology, with operational skills for managing discovery programs at the level of a team leader and a proven track record of delivering clinical candidates is much desirable.
  • Candidates will have a track record of successful contributions to, and leadership of, innovative drug discovery projects, exemplified by a record of patent inventorship, conference presentation and peer-reviewed publication.
  • Expert knowledge of modern methods of synthetic and medicinal chemistry with ability to successfully and simultaneously conduct medicinal chemistry on multiple projects is required
  • Solid understanding of cellular /molecular biology, biochemistry, disease pharmacology, mechanisms of drug metabolism and molecular toxicology, pharmaco-kinetic and pharmaco-dynamic sciences, and the formulations for the in vivo evaluation of drug candidates is required
  • Strong knowledge of computational chemistry methods and working knowledge of biophysical methods
  • Experience in leading multi-disciplinary, cross-functional teams to advance projects, with involvement in supporting cross-company/external collaborations or partnerships is preferred
  • Ability to integrate multiple R&D disciplines into a successful strategy and project plan is required
  • Candidate must have strong problem solving skills for developing creative, innovative solutions and meeting project objectives
  • Candidate must have demonstrated influence, negotiation, and conflict resolution skills, including the ability to succeed as a team player
  • Strong oral and written communications skills in English.

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