职位描述:
As a medicinal chemistry leader, drive and direct medicinal chemistry functions for one or more drug discovery projects. The main job functions include:
- Working in concert with partners in molecular and cellular biology, pharmacology, molecular informatics, ADME, structural biology, chemical development, and other key functions;
- Analyze screening data, perform literature reviews, design, propose, and execute medicinal chemistry plans, coordinate chemistry and biology data to support compound progression and patent strategies;
- Involved in supervising and/or directing synthetic chemistry activities internally;
- Participate in shaping and implementing strategies that support Medicinal Chemistry growth objectives;
- Serve as a scientific expert in medicinal chemistry and provide recommendations regarding new targets and emerging external opportunities;
- Ensure optimal interaction/communication and provide updates on project status to the client.
任职资格:
- PhD in synthetic or medicinal chemistry is required, preferably with postdoctoral experience
- At least 5+ years of experience in the biotechnology or pharmaceutical industry with a proven track record of innovative projects and key contributions to clinical candidate selection.
- Prior project leadership is required
- Broad experience and proven accomplishments in a field of Medicinal Chemistry, preferably in one or more fields of oncology, immunology and virology, with operational skills for managing discovery programs at the level of a team leader and a proven track record of delivering clinical candidates is much desirable.
- Candidates will have a track record of successful contributions to, and leadership of, innovative drug discovery projects, exemplified by a record of patent inventorship, conference presentation and peer-reviewed publication.
- Expert knowledge of modern methods of synthetic and medicinal chemistry with ability to successfully and simultaneously conduct medicinal chemistry on multiple projects is required
- Solid understanding of cellular /molecular biology, biochemistry, disease pharmacology, mechanisms of drug metabolism and molecular toxicology, pharmaco-kinetic and pharmaco-dynamic sciences, and the formulations for the in vivo evaluation of drug candidates is required
- Strong knowledge of computational chemistry methods and working knowledge of biophysical methods
- Experience in leading multi-disciplinary, cross-functional teams to advance projects, with involvement in supporting cross-company/external collaborations or partnerships is preferred
- Ability to integrate multiple R&D disciplines into a successful strategy and project plan is required
- Candidate must have strong problem solving skills for developing creative, innovative solutions and meeting project objectives
- Candidate must have demonstrated influence, negotiation, and conflict resolution skills, including the ability to succeed as a team player
- Strong oral and written communications skills in English.